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Related Experiment Video

Updated: Jan 14, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

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Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic

Robyn E Wootton1,2,3,4, James J Crowley5,6, Josep Pol-Fuster5

  • 1School of Psychological Science, University of Bristol, Bristol, UK.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|January 13, 2026
PubMed
Summary

This study found no strong genetic links between obsessive-compulsive disorder (OCD) and cardiometabolic disorders. Genetic correlation and Mendelian randomization analyses did not reveal shared genetic causes or direct causal effects.

Keywords:
Mendelian randomizationcardiovascular disorderscausalitygenetic correlationsmetabolic conditionsobsessive‐compulsive disorder

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Area of Science:

  • Psychiatry
  • Cardiology
  • Genetics
  • Epidemiology

Background:

  • Obsessive-compulsive disorder (OCD) is linked to higher risks of cardiometabolic disorders.
  • The underlying mechanisms connecting OCD and cardiometabolic health remain unclear.
  • Understanding these links is crucial for public health and clinical interventions.

Purpose of the Study:

  • To investigate shared genetic etiology between OCD and 14 cardiometabolic phenotypes.
  • To explore potential causal relationships between genetic liability to OCD and cardiometabolic traits.
  • To examine indirect causal effects via health behaviors if direct causality is found.

Main Methods:

  • Genetic correlation analyses were performed to assess shared genetic influences.
  • Bi-directional summary-level Mendelian randomization (MR) was used to infer causality.
  • Multivariable MR was planned to explore indirect effects, but not conducted due to lack of direct causal evidence.

Main Results:

  • No significant genetic correlations were found between OCD and most cardiometabolic phenotypes.
  • A notable negative genetic correlation was observed between OCD and body mass index (BMI).
  • Summary-level MR analyses did not support causal effects between OCD and cardiometabolic disorders.

Conclusions:

  • Limited evidence suggests shared genetic etiology or causal effects between OCD and cardiometabolic disorders.
  • The study was primarily powered to detect medium to large effects, leaving open the possibility of smaller causal influences.
  • Larger, more representative samples are needed for further investigation into potential subtle genetic links.