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Cognitive profiles in dementia

Edith Labos1, Diana Cristalli2, Florencia Deschle3

  • 1PhD, Prof. Titular Consulta, Instituto de Salud Pública. Área de Investigación de Funciones Cognitivas, Facultad de Medicina, Universidad de Buenos. edithlabos@gmail.com.

Vertex (Buenos Aires, Argentina)
|January 13, 2026
PubMed
Summary
This summary is machine-generated.

Diagnosing dementia is challenging due to overlapping symptoms across various forms like Alzheimer's and vascular dementia. This study details cognitive profiles to aid in differential diagnosis when advanced tests aren't available.

Keywords:
Dementiacognitive profilesAlzheimer´s diseasevascular cognitive impairementfrontotemporal dementiaLewy body dementiaParkinson diseaseLATE

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Area of Science:

  • Neurology
  • Cognitive Science
  • Geriatrics

Background:

  • Dementia presents with progressive cognitive and functional decline.
  • Alzheimer's disease is most common, but other forms like vascular dementia, frontotemporal dementia, and Lewy body dementia pose diagnostic challenges.
  • Early-stage dementia often shows overlapping clinical and cognitive symptoms, complicating accurate diagnosis.

Purpose of the Study:

  • To provide an updated overview of cognitive profiles in various dementia types.
  • To offer clinical utility for differential diagnosis of dementia.
  • To guide clinicians in identifying dementia subtypes based on cognitive patterns.

Main Methods:

  • Review and description of cognitive profiles for major dementia types.
  • Focus on initial presentation and progression patterns.
  • Consideration of clinical utility in the absence of advanced neuroimaging or biomarkers.

Main Results:

  • Detailed cognitive profiles for Alzheimer's disease, vascular dementia, behavioral variant frontotemporal dementia, Lewy body dementia, primary progressive aphasias, Parkinson's disease dementia, and late-onset dementia (LATE).
  • Highlights the heterogeneity and overlapping features that complicate diagnosis.
  • Emphasizes the importance of distinct cognitive patterns for differentiation.

Conclusions:

  • Understanding specific cognitive profiles is crucial for differential diagnosis of dementia.
  • This cognitive-based approach offers practical clinical value, especially when complex diagnostics are inaccessible.
  • A clear grasp of cognitive trajectories aids in timely and accurate dementia diagnosis.