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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Validation of the Autism Mental Status Exam in Spanish: sensitivity and specificity in an Argentine clinical sample

Sebastián H Cukier1, Ana Maglio2, Jonathan Berman3

  • 1Médico especialista en Psiquiatría infantojuvenil, Jefe de Salud Mental y Psicopatología, Hospital Pediátrico "Pedro de Elizalde", CABA, Argentina, Co-director médico de Fundación Ados. . sebastiancukier@gmail.com.

Vertex (Buenos Aires, Argentina)
|January 13, 2026
PubMed
Summary
This summary is machine-generated.

The Autism Mental Status Examination (AMSE) in Spanish demonstrated high accuracy in identifying autism spectrum disorder (ASD). This brief clinical tool is reliable and culturally adapted for Spanish-speaking regions with limited resources.

Keywords:
Autism mental status examautism spectrum disorderautism diagnostic assessmentArgentinaLatin America

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Area of Science:

  • Psychiatry
  • Developmental Psychology
  • Clinical Psychology

Background:

  • The Autism Mental Status Examination (AMSE) is a brief, clinician-completed instrument for observing and documenting socio-communicative and behavioral features of autism.
  • The original English version of AMSE showed high accuracy in identifying autism spectrum disorder (ASD).
  • Adaptation and validation of diagnostic tools are crucial for diverse populations, especially in resource-limited settings.

Purpose of the Study:

  • To explore the sensitivity and specificity of a Spanish-language version of the AMSE in an Argentinian sample.
  • To evaluate the diagnostic utility of AMSE for identifying ASD against DSM-5 clinical consensus diagnoses.
  • To assess the psychometric properties, including internal consistency and inter-rater reliability, of the Spanish AMSE.

Main Methods:

  • A sample of 313 subjects was assessed using the Spanish AMSE.
  • Receiver Operating Characteristic (ROC) curve analysis was employed to determine optimal cut-off values, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).
  • Internal consistency was evaluated using Cronbach's alpha, and inter-rater reliability was assessed with Cohen's Kappa.

Main Results:

  • The Spanish AMSE achieved an optimized sensitivity of 90.71% and a specificity of 92.17% in the Argentinian sample.
  • The instrument demonstrated acceptable internal consistency (Cronbach's alpha = .75) and high inter-rater reliability (Kappa = .97).
  • These findings indicate robust psychometric properties for the Spanish version of AMSE.

Conclusions:

  • The Spanish AMSE is a promising and clinically useful tool for the diagnostic evaluation of ASD in at-risk children, adolescents, and adults.
  • Its application is particularly relevant in Latin America, where access to gold-standard diagnostic scales may be limited.
  • AMSE provides a brief, reliable, and culturally adapted diagnostic aid for autism in Spanish-speaking contexts with limited resources.