Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and performance of vibration-assisted extraction of chronic cardiac implantable electronic device leads: A pre-clinical ovine study.

Heart rhythm·2026
Same author

Clinical and Histopathological Evaluation of Maximal and Supramaximal Energy Direct Selective Laser Trabeculoplasty (DSLT): A Rabbit Model Safety Study.

Lasers in surgery and medicine·2026
Same author

Redox- and Photo-Responsive Fe<sup>3+/2+</sup>-Cross-Linked Carboxymethyl Cellulose Methacrylate Dissipative Gels: Synthesis and Applications.

ACS applied materials & interfaces·2026
Same author

Saroglitazar, a novel PPAR-α/γ agonist, modulates thyroid hormone homeostasis through hepatic UGT expression in wistar rats.

Chemico-biological interactions·2026
Same author

Solid Pro-Nano Lipid Oral Formulations for Cannabidiol (CBD).

Pharmaceutics·2026
Same author

Non-invasive quantification of viability in liver spheroids using deep learning.

Frontiers in bioengineering and biotechnology·2026
Same journal

A DLP-Printed 3D Bioceramplug Fabricated Using a Photocurable Negative Thermo-Responsive Bioceramic Slurry for Cranial Burr-Hole Repair.

ACS biomaterials science & engineering·2026
Same journal

A Microenvironment-Driven Peptide Nanoplatform Enhances Ferroptosis and Antiangiogenic Activity for Triple-Negative Breast Cancer Therapy.

ACS biomaterials science & engineering·2026
Same journal

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same journal

Biomimetic 3D-Printed Resorbable Extracellular Matrix-Guided Bone Regeneration Membrane Based on a Gelatin Methacrylate/Alginate-Hydroxyapatite Composite for Maxillofacial Surgery.

ACS biomaterials science & engineering·2026
Same journal

Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin-Tazobactam.

ACS biomaterials science & engineering·2026
Same journal

Retinoic Acid-Functionalized Chitosan Polycationic Conjugates for Integrated Melanoma Therapy and Antibacterial Infection Control.

ACS biomaterials science & engineering·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

9.5K

Injectable Cisplatin-Loaded Biodegradable Poly(anhydride-ester) for Treating Head and Neck Cancer: Preclinical

Christine Warwar Damouny1, Narmeen Matta1, Muhammad Abdel Haq2,3

  • 1Intragel Therapeutics LTD., Wadi El Haj 13, PO Box 1252, Nazareth Industrial Area, Nazareth 17111, Israel.

ACS Biomaterials Science & Engineering
|January 13, 2026
PubMed
Summary
This summary is machine-generated.

A novel long-acting cisplatin formulation using biodegradable polymers aims to reduce severe toxicity in head and neck cancer patients. This approach may improve treatment adherence and patient outcomes for squamous cell carcinoma of head and neck (SCCHN).

Keywords:
FaDu xenograftP(SARA)biodegradablecisplatinhead and neck cancerinjectableintratumorallong-actingpolyanhydride

More Related Videos

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.9K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.3K

Related Experiment Videos

Last Updated: Jun 17, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

9.5K
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.9K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.3K

Area of Science:

  • Oncology
  • Drug Delivery Systems
  • Biomaterials Science

Background:

  • Standard first-line treatment for unresectable HPV-negative squamous cell carcinoma of head and neck (SCCHN) combines cisplatin chemotherapy with radiotherapy.
  • Cisplatin's severe systemic toxicity limits its use in some patients, leading to suboptimal treatment and poorer prognosis.
  • Alternative treatments are less effective, highlighting the need for improved cisplatin delivery methods.

Purpose of the Study:

  • To investigate a novel, single-dose, long-acting cisplatin formulation to mitigate systemic toxicity.
  • To evaluate the potential of a biodegradable polyanhydride carrier for targeted, high-payload drug delivery.
  • To enhance the safety and efficacy of cisplatin-based therapy for SCCHN.

Main Methods:

  • Development of an injectable, biodegradable polyanhydride carrier system.
  • Formulation of a long-acting cisplatin using sebacic acid (SA) and ricinoleic acid (RA).
  • Investigation of the carrier's potential for small-volume, high-payload drug delivery.

Main Results:

  • The developed polyanhydride carrier system demonstrates potential for single-dose, long-acting cisplatin delivery.
  • The formulation is designed to reduce systemic toxicity associated with conventional cisplatin chemotherapy.
  • The targeted delivery approach aims to improve therapeutic efficacy in SCCHN treatment.

Conclusions:

  • A novel biodegradable polyanhydride carrier offers a promising strategy for developing a less toxic, long-acting cisplatin formulation.
  • This innovative drug delivery system could improve treatment adherence and outcomes for SCCHN patients.
  • Further research is warranted to fully establish the safety and efficacy of this new cisplatin delivery method.