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Multivariate regression reveals linear correlation between ICU Klebsiella pneumoniae resistance and antibiotic use

Fangyuan Xia1, Yu Pan1, Sucai Chen2

  • 1Department of Pharmacy, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang, China.

Journal of Infection in Developing Countries
|January 13, 2026
PubMed
Abstract

Insights

Klebsiella pneumoniae resistance in the ICU is linked to antimicrobial drug use. Regulating antibiotic use is crucial to combat rising resistance and improve patient outcomes.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Antimicrobial Stewardship

Background:

  • Investigated the correlation between Klebsiella pneumoniae resistance and antimicrobial use in ICUs.
  • Aimed to guide treatment for chronic infections and curb resistance spread.

Purpose of the Study:

  • To analyze the macro-quantitative correlation between K. pneumoniae resistance rates and concurrent antimicrobial use in the ICU.
  • To identify factors influencing resistance and optimize patient outcomes.

Main Methods:

  • Retrospective analysis of K. pneumoniae isolates and antimicrobial agent usage in the ICU.
  • Employed multiple linear regression to assess correlations and identify relevant factors.

Main Results:

  • Over 65% resistance rates observed for most antimicrobials, except tigecycline and trimethoprim-sulfamethoxazole.
  • K. pneumoniae resistance to imipenem, piperacillin-tazobactam, and ceftazidime correlated with piperacillin-tazobactam use.
  • Other resistance patterns showed correlations with specific antimicrobial defined daily doses (DDDs).

Conclusions:

  • K. pneumoniae resistance rates in the ICU are significantly associated with antimicrobial prescribing patterns.
  • Hospitals must enhance antimicrobial use regulation to mitigate the emergence of drug-resistant bacteria.
Keywords:
Klebsiella pneumoniaeintensive care unitlinear correlationmultiple linear regression analysis

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