Related Experiment Video

Updated: Jan 15, 2026

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
03:05

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors

Published on: February 16, 2024

1.5K

Relationship between Helicobacter pylori infection and different pathological types of chronic atrophic gastritis and

Yuexia Zhang1, Yanping Feng1, Conglei You1

  • 1Department of Health Management Center, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100096, China.

Journal of Infection in Developing Countries
|January 13, 2026
PubMed

Insights

Helicobacter pylori infection is linked to chronic atrophic gastritis (CAG). Combining Hp testing with serum gastric function tests aids in assessing atrophy severity and type.

Area of Science:

  • Gastroenterology
  • Pathology
  • Clinical Diagnostics

Background:

  • Chronic atrophic gastritis (CAG) is a precancerous condition.
  • Helicobacter pylori (Hp) infection is a major risk factor for CAG.
  • Understanding the relationship between Hp infection, gastric function, and CAG subtypes is crucial for diagnosis and management.

Purpose of the Study:

  • To compare Helicobacter pylori infection rates and serum gastric function in different pathological types of chronic atrophic gastritis (CAG).
  • To evaluate the combined diagnostic value of Hp status and serum gastric function tests for assessing CAG extent and severity.

Main Methods:

  • Retrospective analysis of 60 CAG patients and 46 chronic non-atrophic gastritis (CNAG) patients.
  • Comparison of endoscopic findings, histopathology, Hp status, and serum gastric function indices (pepsinogen I, pepsinogen II, gastrin-17).

Main Results:

  • CAG patients exhibited higher Hp positivity and gastrin-17 levels, with lower pepsinogen I and II levels compared to CNAG patients.
  • Within CAG, open-type and intestinal metaplasia subtypes showed significantly higher Hp rates and gastrin-17, alongside lower pepsinogen levels than closed-type and glandular reduction subtypes, respectively.
  • Significant differences (p < 0.01) were observed in Hp rates and serum gastric function across different pathological and microscopic CAG types.

Conclusions:

  • Helicobacter pylori infection is strongly associated with chronic atrophic gastritis.
  • Distinct Hp infection rates and serum gastric function profiles exist across various pathological and microscopic CAG types.
  • Combined assessment of serum gastric function and Hp status effectively aids in evaluating the extent and severity of gastric atrophy.
Abstract

Keywords:
Chronic atrophic gastritisHelicobacter pyloriendoscopic classificationpathological typeserum gastric function

More Related Videos

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology05:13

Rapid Detection of Helicobacter pylori Virulence and Typing Using Quantum Dot Labeling Technology

Published on: June 13, 2025

727
Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

399

Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
2.1K
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.1K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
534
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
740
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
1.2K