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A Brief Mindfulness Intervention for Pain Management in Fibromyalgia: A Single-arm Open-Label Study.

Perianen Ramasawmy1,2, Luise Charlotte Heim1, Elisabeth Fechner1

  • 1Non-Invasive Brain Stimulation Lab, Department of Neurology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.

Restorative Neurology and Neuroscience
|January 13, 2026
PubMed
Summary

This study explored a mindfulness-based intervention (MBI) for fibromyalgia, finding statistically significant pain reduction but limited clinical improvement. Further research is needed to confirm the MBI

Keywords:
fibromyalgiahome-based therapymeditationmindfulnesstranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Fibromyalgia is a chronic condition characterized by widespread pain and significant quality of life impairment.
  • Current treatment options offer limited efficacy for many patients, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To evaluate the preliminary therapeutic effects of a novel, four-week mindfulness-based intervention (MBI) specifically tailored for fibromyalgia patients.
  • To assess the impact of the MBI on pain intensity, affective pain, quality of life, sleep, mood, emotion regulation, and psychological impairment.
  • To investigate mindfulness-induced changes in cortical excitability using transcranial magnetic stimulation.

Main Methods:

  • An open-label, single-arm study involving 46 fibromyalgia patients who completed a four-week MBI.
  • Intervention included weekly online group sessions and daily mindfulness practices.
  • Outcomes measured included numerical rating scale for pain, verbal fluency, self-report questionnaires, and transcranial magnetic stimulation for cortical excitability.

Main Results:

  • Statistically significant reductions in pain intensity were reported post-intervention.
  • A moderate improvement in quality of life was observed, with 45.6% clinical responders.
  • Small-to-medium improvements noted in affective pain, mindfulness, resilience, and GABAergic inhibition (long-interval intracortical inhibition).

Conclusions:

  • The study introduces a novel MBI for fibromyalgia, demonstrating statistically significant but not consistently clinically meaningful improvements.
  • The findings suggest potential benefits but are limited by the study design and lack of clinical significance.
  • Sham-controlled randomized clinical trials are required to validate the efficacy of this MBI for fibromyalgia.