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Published on: June 14, 2016
TMEM16A regulates MUC5AC production in airway diseases: A comprehensive review
Jintao Gan1, Xiaochun Huang1, Danli Zhu1
1Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China; Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China.
Abstract:
Abnormal secretion of the airway mucin MUC5AC is a key pathological feature in the pathologic process of airway diseases, overproduction of MUC5AC leads to airway mucus accumulation and airway obstruction, which further triggers respiratory dysfunction and seriously threatens the health of patients. In recent years, studies have begun to focus on the role of transmembrane protein 16A (TMEM16A) in regulating the secretion of mucin MUC5AC in airway epithelial cells. Studies have shown that TMEM16A may play an important role in regulating MUC5AC secretion, and its precise regulation of MUC5AC profoundly affects the process of airway mucus secretion and inflammatory response, and plays a key role in the occurrence and development of airway diseases. In this paper, we mainly review the latest research progress of TMEM16A's effect on the production of mucus protein MUC5AC in airway diseases in recent years, aiming to provide new ideas and directions for the follow-up research in this field as well as for the optimization of clinical therapeutic strategies.
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