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Updated: Jan 15, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Prognostic value of left atrial strain analysis in patients with chronic myocarditis

Yuting Zou1, Zhongwei Yuan2, Xinyi Wang2

  • 1Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwu Road, Jinan 250021, China.

International Journal of Cardiology
|January 13, 2026
PubMed

Insights

Left atrial strain, measured by cardiac MRI, predicts outcomes in chronic myocarditis. These measures are reliable for ruling out adverse cardiovascular events in patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Prognostics

Background:

  • Left atrial (LA) strain and LA atrioventricular coupling index (LACI) are known prognostic markers in cardiovascular diseases.
  • Their predictive value in chronic myocarditis is not well-established.

Purpose of the Study:

  • To assess the prognostic significance of cardiac MRI (CMR)-derived LA strain and LACI in patients with chronic myocarditis.
  • To determine if these parameters can predict adverse cardiovascular events.

Main Methods:

  • Retrospective analysis of 113 patients with suspected chronic myocarditis undergoing CMR.
  • Collected data on LA functional parameters, LACI, clinical factors, and outcomes.
  • Used multivariable Cox regression to identify independent predictors of composite endpoints (major adverse cardiovascular events and arrhythmias).

Main Results:

  • LA reservoir strain and LA conduit strain independently predicted composite events (P=0.003 and P=0.007, respectively).
  • These LA strain parameters demonstrated high negative predictive values and sensitivities for ruling out events.
  • A combined model of LA reservoir and conduit strains achieved excellent predictive performance (AUC=0.90).

Conclusions:

  • CMR-derived LA reservoir and conduit strains are independent predictors of adverse outcomes in chronic myocarditis.
  • These LA strain measures serve as effective "rule-out" tools for cardiovascular events in this patient group.
  • The combined analysis of LA strains offers robust predictive capability for adverse outcomes.
Abstract

Keywords:
Left atriumMagnetic resonance imagingMyocarditisPrognosis

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