[Specificities of allogeneic stem cell transplantation for sickle cell disease (SFGM-TC)]

Sickle cell disease affects approximately 30,000 people in France. Between 1988 and 2022, 700 patients underwent allogeneic hematopoietic stem cell transplantation (HSCT), mainly children, but the procedure is increasingly offered to adults. The medical and psychological complexities of transplantation in this population require specific attention to optimize care.

Our work was based on a literature review and team experience, following the standard methodology of the SFGM-TC. Our focus was on pre-transplant evaluation, transfusion preparation, fertility preservation, post-transplant medical follow-up, psychological support, and pain management.

Transplantation for sickle cell disease requires comprehensive assessment of organ damage, transfusion preparation, and close interdisciplinary collaboration. Fertility is a major concern, with tailored protocols based on the patient's sex and age. Post-transplant pain, often complex, necessitates multidisciplinary follow-up and team awareness. Psychologically, the post-transplant transition is marked by a loss of bearings, requiring personalized psychological support.

Interdisciplinary collaboration, meticulous preparation, and long-term follow-up are essential to improving transplant outcomes in sickle cell patients. Enhanced team awareness and the involvement of expert patients are also recommended.