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Bromination Functionalization of Diazo Compounds with CBr4 via Convergent Paired Electrolysis
Qian Wang1, Wentian Wu1, Haibo Mei1
1Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
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An electrochemical bromination of diazo compounds with CBr4 as a bromine source via convergent paired electrolysis has been developed, which affords α-bromo phosphonates as products in up to 96% yields. This work represents the first example of direct anodic oxidation of diazos to couple with an in situ-generated nucleophile from the cationic reduction of CBr4 by using CH2Cl2 as a hydrogen source. This reaction features mild conditions, good substrate compatibility, and scale-up applicability, which represents a new electrochemical reaction mode of diazo compounds and also provides easy access to α-bromo phosphonates.
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