Data-driven visualization of silica-based nanobiomaterial dynamics for tissue regeneration

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Silica-based nanobiomaterials (SNs) are increasingly vital in regenerative medicine.
• A comprehensive analysis of SN research trends and evolution is lacking.
• Understanding development trajectories is crucial for future advancements.

Purpose of the Study:

• To systematically analyze the publication trends, research hotspots, and future prospects of SNs in regenerative medicine.
• To identify key countries, institutions, and journals contributing to SN research.
• To map the evolution and thematic focuses of SN applications in regenerative medicine.

Main Methods:

• Bibliometric analysis of 853 research articles (2006-2025) from the Science Citation Index Expanded.
• Utilized CiteSpace, VOSviewer, and Biblioshiny for data visualization and analysis.
• Examined publication trends, country/institution contributions, journal distribution, and keyword dynamics.

Main Results:

• Significant acceleration in research output on SNs in regenerative medicine.
• China leads in publication volume, while the United States excels in citation impact.
• Key research areas include drug delivery, antimicrobial activity, bone regeneration, and wound healing.
• Emerging research frontiers identified: mesoporous bioactive glass nanoparticles, wound healing, and zinc ion dopants.

Conclusions:

• SNs represent a rapidly evolving field within regenerative medicine.
• Strategic insights into research impact and emerging trends can guide future development.
• Further research into novel SN compositions and applications is warranted to address clinical needs.