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Updated: Jan 15, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
Maternal phylloquinone intake and early neurodevelopment: implications for prenatal nutrition
Khaled Saad1, Zakaria M Abdel-Sadek2, Eman F Gad3
1Department of Pediatrics, Assiut University, Assiut, Egypt. Khaled.ali@med.au.edu.eg.
Impact:
Vitamin K supports neurodevelopment through sphingolipid regulation critical for myelination and neuronal integrity, anti-inflammatory effects via NF-κB pathway inhibition, and improved maternal glucose metabolism and insulin sensitivity. Current prenatal recommendations of vitamin K (70-90 µg/day), based solely on coagulation needs, may be insufficient for optimal brain development. A target of 140 µg/day warrants consideration in future guidelines. Routine assessment of vitamin K status in prenatal care offers a safe and low-cost opportunity to support neurodevelopment and reduce developmental inequities at the population level.
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