Related Experiment Video
Updated: Jan 15, 2026
Accessing the Subdural Space of the Rodent Spinal Cord for Treatment Delivery
Published on: August 8, 2025
Endoscopic repair of large dural defects in transsphenoidal surgery by suturing acellular dermal matrix graft with
Wei Quan1, Sheng-Li Hu1, Da-Wei Zhao1
1Department of Neurosurgery, Southwest Hospital, Army Medical University (Third Military Medical University), No. 30, Gaotanyan, Shapingba District, Chongqing, 400038, China.
Objective:
To introduce acellular dermal matrix (ADM) suturing as a novel repair method for intraoperative high-flow cerebrospinal fluid (CSF) leakage during transsphenoidal surgery (TSA), aiming to replace autologous fat/fascia lata grafts and reduce surgical morbidity.
Methods:
Five patients (2 invasive pituitary adenomas, 2 craniopharyngiomas, 1 epidermoid cyst) underwent total sellar/suprasellar tumor resection and presented intraoperative high-flow CSF leakage. ADM grafts were tailored to dural defects and sutured directly to native dural edges. Outcomes included repair integrity, operative efficiency, and postoperative complications (CSF leakage, infection).
Results:
All cases achieved dural closure without autologous tissue harvesting. Mean operative time was reduced by avoiding graft harvest procedures. No postoperative CSF leakage or intracranial infections occurred. At 30-day follow-up, all patients exhibited satisfactory recovery with stable skull base reconstruction.
Conclusion:
ADM suture repair eliminates donor-site morbidity and shortens operative time while providing robust dural sealing. This technique may be a promising alternative to conventional autologous grafts for high-flow CSF leakage management, warranting larger-scale validation.
