Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Phases of Wound Repair

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Special Issue "Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration".

International journal of molecular sciences·2026

Same author

Obstetric and Neonatal Outcomes Following Immediate Delivery Versus Expectant Management in Pregnant Women With Preterm Premature Rupture of Membranes During the Late Preterm Period in Korea.

Journal of Korean medical science·2026

Same author

Economic Low-Carbon Chemical Production via Paired Electrolysis of Carbon Monoxide (CO) and 5-hydroxymethylfurfural (HMF).

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

A comparative analysis of regulatory frameworks and their market impacts on health functional foods: perspectives from South Korea, Canada, the United States, and China.

Critical reviews in food science and nutrition·2026

Same author

Perinatal outcomes of expectant management versus fetal reduction in triplet pregnancies: A single-center retrospective cohort study in Korea.

Acta obstetricia et gynecologica Scandinavica·2026

Same author

iNOS in Macrophage Polarization: Pharmacological and Regulatory Insights.

International journal of molecular sciences·2025

Search research articles

Related Experiment Video

Updated: Jan 15, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Nanoformulated PDRN Improves Anti-Inflammatory and Wound Healing Activities.

Ji-Hye Kang¹, Min Jeong Jeon², Sung-Eun Kim²

¹Department of Medical Biotechnology, College of Medical Science, Soonchunhyang University, Asan, Chungnam, Republic of Korea.

Macromolecular Bioscience

|January 14, 2026

Summary

Polydeoxyribonucleotide (PDRN) was encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles to improve its stability and therapeutic efficacy for skin inflammation and wound healing.

Keywords:

LPS‐induced inflammatory wound healing PDRN‐loaded PLGA nanoparticles anti‐inflammatory polydeoxyribonucleotide skin regeneration

More Related Videos

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jan 15, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

Area of Science:

Biomaterials Science
Regenerative Medicine
Pharmacology

Background:

Polydeoxyribonucleotide (PDRN) promotes anti-inflammatory responses and wound healing via adenosine A2A receptor activation.
Low molecular weight PDRN is prone to rapid degradation, limiting its therapeutic effectiveness.
Developing stable PDRN formulations is crucial for enhanced regenerative therapies.

Purpose of the Study:

To develop a scalable method for producing high-purity, low molecular weight PDRN.
To encapsulate PDRN within poly(lactic-co-glycolic acid) (PLGA) nanoparticles to enhance stability and delivery.
To evaluate the anti-inflammatory and wound-healing efficacy of PDRN/PLGA nanoparticles.

Main Methods:

Produced low molecular weight PDRN (approx. 325 bp) from calf thymus DNA using physical fragmentation.
Encapsulated PDRN in PLGA to create PDRN/PLGA nanoparticles (336 ± 43 nm).
Assessed nanoparticle characteristics (stability, biodegradability, PDRN release) and PDRN protection against degradation.

Main Results:

PDRN/PLGA nanoparticles demonstrated excellent colloidal stability and biodegradability (38.3% over 14 days).
Sustained PDRN release (88.39% over 14 days) and effective protection against thermal, acidic, enzymatic, and UV degradation.
PDRN/PLGA nanoparticles showed superior anti-inflammatory and wound-healing efficacy in vitro compared to free PDRN, with no cytotoxicity.

Conclusions:

Nanoencapsulation effectively protects low molecular weight PDRN, significantly enhancing its therapeutic activity.
PDRN/PLGA nanoparticles represent a stable and effective platform for treating skin inflammation and promoting regeneration.
This approach holds promise for improving regenerative therapies for inflammatory skin conditions.