Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatic Encephalopathy01:29

Hepatic Encephalopathy

71
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...
71
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

68
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
68

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Local performance and fairness testing of an AI Scribe in a paediatric developmental assessment clinic in South Australia: a silent trial protocol.

BMJ open·2026
Same author

The Year in Electrophysiology: Selected Highlights From 2025.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

The External Globus Pallidus is a Basal Ganglia Output Hub with Action-Specific Circuits.

bioRxiv : the preprint server for biology·2026
Same author

"I feel good… I knew that I would…": The role of self in musical reward across cultures.

PloS one·2026
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Exploring the liver microenvironment following successful therapy for HCV: gene expression profiling and residual T cell infiltration.

Frontiers in cellular and infection microbiology·2025

Related Experiment Video

Updated: May 5, 2026

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

1.0K

MASLD-Induced Hyperammonemia With Atypical, Restricted Diffusion Pattern Suggesting Mixed Metabolic and

Renu Thomas1, Nhuchau Tiffany Nguyen1, Daniel Bao1

  • 1HCA Houston Healthcare Kingwood, Kingwood, Texas.

HCA Healthcare Journal of Medicine
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

High ammonia levels in cirrhosis can cause altered mental status and brain imaging abnormalities mimicking hypoxic injury. Prompt treatment with laxatives can normalize ammonia and resolve these neurological and radiologic findings.

Area of Science:

  • Neurology
  • Gastroenterology
  • Radiology

Background:

  • Hepatic encephalopathy (HE) is a common complication of decompensated cirrhosis, causing altered mental status.
Keywords:
ammoniahepatic encephalopathyhyperammonemiahypoxic-anoxic brain injurymagnetic resonance imaging

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.6K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.0K

Related Experiment Videos

Last Updated: May 5, 2026

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

1.0K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.6K
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
11:02

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

1.0K
  • Untreated HE can lead to severe neurologic sequelae, including cerebral edema and herniation.
  • Hyperammonemia in HE can cause diffusion patterns mimicking hypoxic-anoxic brain injury, even with normal oxygenation.