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Updated: Jan 15, 2026
08:56
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
54.4K
Characterisation and Prognostic Implication of Cholestasis After Burn Injury.
Lorenz Semmler1, Georg Semmler2, Andreas Langa1
1Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.
Alimentary Pharmacology & Therapeutics
|January 14, 2026
Summary
Cholestasis is common in burn patients and linked to poor outcomes. Monitoring bilirubin levels can identify patients at high risk for mortality, regardless of burn severity.
Area of Science:
- Critical Care Medicine
- Hepatology
- Burn Surgery
Background:
- Cholestasis frequently complicates burn injuries, correlating with adverse patient outcomes.
- Understanding the patterns and predictors of cholestasis in burn patients is crucial for improving care.
Purpose of the Study:
- To investigate the longitudinal changes in cholestasis markers in burn patients.
- To validate a proposed definition for burn-associated cholestasis (BAC).
Main Methods:
- A retrospective cohort study included 532 intensive care unit (ICU) patients with burn injuries over 10 years.
- Longitudinal data on burn severity, ICU treatments, and laboratory parameters were collected from admission to discharge or death.
Main Results:
- 22% of patients met the criteria for burn-associated cholestasis (BAC).
- Hyperbilirubinemia was independently associated with mortality, particularly after 7 days post-burn.
- Concordant elevations in bilirubin and other liver enzymes aided early risk identification.
Conclusions:
- Cholestasis is a significant complication following burn injury.
- Bilirubin dynamics, rather than burn severity alone, predict prognosis.
- Hyperbilirubinemia is linked to increased mortality risk in burn survivors.
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