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Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension.
So Mi Jemma Cho1,2,3, Yunfeng Ruan1,2, Hyeok-Hee Lee4
1Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA (S.M.J.C., Y.R., S.K., M.C.H., A.C.F., A.P.P., W.E.H., P.N.).
Hypertension (Dallas, Tex. : 1979)
|January 14, 2026
Summary
Genetically predicted blood pressure (BP) using polygenic scores (PGSs) can identify individuals at higher risk for long-term poor BP control and treatment-resistant hypertension. These genetic insights can guide proactive monitoring and intensive treatment strategies for better cardiovascular disease prevention.
Area of Science:
- Cardiovascular Genetics
- Hypertension Research
- Precision Medicine
Background:
- Suboptimal blood pressure (BP) control is a significant risk factor for cardiovascular disease.
- The independent predictive value of genetically predicted BP for long-term BP control is not well understood.
Purpose of the Study:
- To investigate the association between BP polygenic scores (PGSs) and long-term BP control.
- To examine the relationship between BP PGSs and the incidence of treatment-resistant hypertension.
Main Methods:
- Utilized data from 22,456 participants with hypertension from the Mass General Brigham Biobank.
- Defined longitudinal BP control as time above target SBP (≥130 mmHg) or DBP (≥80 mmHg) over 5 years.
- Assessed associations using multivariable regression and validated findings in the UK Biobank cohort.
Main Results:
- Higher BP PGSs were associated with a longer duration of above-target systolic and diastolic BP.
- Individuals with high SBP and DBP PGSs had significantly increased odds of developing treatment-resistant hypertension.
- Incorporating BP PGSs improved the prediction of treatment-resistant hypertension.
Conclusions:
- BP PGSs can predict long-term BP management and treatment-resistant hypertension risk.
- Utilizing BP PGSs may enable proactive monitoring and targeted intensive therapies for improved BP control.
- Genetic risk scores offer valuable insights for personalized hypertension management strategies.
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