Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

43.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Human brain mapping·2026
Same author

A canary in the mind: A single baseline brain scan predicts adolescent depression and anxiety one year later.

medRxiv : the preprint server for health sciences·2026
Same author

Variational autoencoder for explainable seizure onset phases detection.

Journal of neural engineering·2026
Same author

Restoring oscillatory dynamics in Alzheimer's disease: A laminar whole-brain model of serotonergic psychedelic effects.

Network neuroscience (Cambridge, Mass.)·2026
Same author

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

The Algorithmic Regulator.

Entropy (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 15, 2026

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

1.2K

Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers.

Roser Sanchez-Todo1,2, Borja Mercadal1, Edmundo Lopez-Sola1,2

  • 1Brain Modeling Department, Neuroelectrics Barcelona, Barcelona, Spain.

Human Brain Mapping
|January 14, 2026
PubMed
Summary

Parvalbumin-positive interneuron dysfunction drives early hyperexcitability in Alzheimer's disease (AD). This dysfunction, simulated using a neural mass model, accurately predicts AD's progression to hypoactivity, implicating neuronal loss in later stages.

Keywords:
Alzheimer's diseaseM/EEG biomarkerslaminar neural mass modelparvalbumin‐positive interneurons

More Related Videos

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

9.3K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.2K

Related Experiment Videos

Last Updated: Jan 15, 2026

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

1.2K
Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

9.3K
Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

7.2K

Area of Science:

  • Computational neuroscience
  • Neurodegenerative disease modeling
  • Electrophysiology

Background:

  • Alzheimer's disease (AD) progression involves cortical hyperexcitability shifting to hypoactivity.
  • Parvalbumin-positive (PV) interneuron dysfunction and neuronal loss, driven by amyloid-beta (Aβ) and hyperphosphorylated tau (hp-τ), are implicated but mechanisms are unclear.

Purpose of the Study:

  • To investigate the mechanistic link between PV interneuron dysfunction and the biphasic electrophysiological changes observed in AD.
  • To model the progression of AD-related neural activity using a computational approach.

Main Methods:

  • A Laminar Neural Mass Model integrating excitatory and inhibitory populations was developed.
  • Synaptic coupling from PV interneurons to pyramidal cells was reduced to simulate Aβ-induced neurotoxicity.
  • Model simulations analyzed dipole activity in the time-frequency domain, with parameter variations exploring alternative mechanisms like hp-τ pathology.

Main Results:

  • Simulated PV interneuron dysfunction replicated AD's biphasic progression: initial hyperexcitability (elevated gamma/alpha power) followed by oscillatory slowing and reduced spectral power.
  • Alternative mechanisms like increased excitatory drive did not reproduce this trajectory.
  • Incorporating pyramidal cell disruption (hp-τ) aligned model output with late-stage hypoactivity and reduced firing rates.

Conclusions:

  • PV interneuron dysfunction is a primary driver of early electrophysiological disruption in AD.
  • Pyramidal cell loss contributes to late-stage hypoactivity, providing a mechanistic model for excitation-inhibition imbalance throughout AD progression.