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Critical Temperature Thresholds for Identifying Vulnerability to Heat-Related Excess Cardiovascular Morbidity and
Peter M Graffy1,2,3, Benjamin W Barrett1,2, Daniel E Horton4
1Health Sciences Integrated Program, Northwestern University Chicago IL USA.
Journal of the American Heart Association
|January 14, 2026
Summary
Extreme heat significantly increases cardiovascular disease (CVD) mortality, with varying temperature thresholds across different time scales. Understanding community vulnerability is key for targeted public health interventions against heat-related risks.
Area of Science:
- Environmental Health
- Epidemiology
- Cardiovascular Disease Research
Background:
- Extreme heat is a known environmental hazard linked to increased cardiovascular disease (CVD) morbidity and mortality.
- Limited research exists on temperature effects across multiple temporal scales and community-specific vulnerability to heat.
Purpose of the Study:
- To analyze the association between temperature and CVD deaths and emergency department visits across various temporal scales.
- To identify community-specific heat vulnerability profiles based on sociodemographic factors and environmental conditions.
Main Methods:
- Utilized neighborhood-level CVD mortality and emergency department visit data, linked with sociodemographic information and high-resolution temperature/humidity estimates.
- Employed generalized additive models to estimate excess heat-related rates across temporal scales.
- Used principal component analysis and k-means clustering to classify community areas by heat vulnerability.
Main Results:
- Higher temperatures showed significant associations with increased CVD and coronary heart disease mortality across warm-season, monthly, and daily scales.
- Peak warm-season thresholds for CVD mortality were observed at 25.6°C, and daily peaks at 39.5°C.
- Identified three distinct community vulnerability profiles based on socioeconomic status, demographics, and heat/humidity exposure.
Conclusions:
- Temperature thresholds for cardiovascular mortality differ by temporal scale and CVD subtype, with significant impacts on overall CVD and coronary heart disease mortality.
- Integrating temperature-mortality data with community vulnerability profiles can enhance heat warning systems and inform localized adaptation strategies.
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