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Related Experiment Videos

Genotype and test experience determine responsiveness to morphine.

R L Collins, G Whitney

    Psychopharmacology
    |January 31, 1978
    PubMed
    Summary
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    Mice strains show different responses to morphine. DBA/2J mice were unresponsive, C57BL/6J mice showed significant effects, and F1 hybrids had intermediate reactions in analgesia and activity tests.

    Area of Science:

    • Pharmacology
    • Genetics
    • Neuroscience

    Background:

    • Individual differences in drug response are common.
    • Genetic background influences opioid sensitivity.
    • Understanding strain-specific effects is crucial for preclinical research.

    Purpose of the Study:

    • To investigate morphine responsiveness in C57BL/6J, DBA/2J mice, and their F1 hybrid.
    • To compare analgesia and locomotor activity effects across different genetic backgrounds.
    • To identify strain-specific differences in initial morphine sensitivity.

    Main Methods:

    • Utilized hot-plate analgesia and locomotor activity tests.
    • Administered three morphine doses: 0 mg/kg, 5 mg/kg, and 15 mg/kg.
    • Compared responses across two inbred mouse strains and their F1 hybrid.

    Related Experiment Videos

    Main Results:

    • DBA/2J mice exhibited no significant morphine effect on either test.
    • C57BL/6J mice demonstrated substantial morphine-induced analgesia and activity changes.
    • F1 hybrid mice displayed intermediate responses to morphine, falling between the parental strains.
    • The 0 mg/kg group revealed strain-specific effects of test experience.

    Conclusions:

    • Significant genetic variation exists in morphine responsiveness between C57BL/6J and DBA/2J mouse strains.
    • Morphine efficacy for analgesia and activity is modulated by genetic background.
    • F1 hybrids show a predictable intermediate response, suggesting additive genetic effects.