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Updated: Jan 15, 2026

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Decreasing Door-to-Analgesia Time: Increasing Use of Sickle Cell Pain Management Pathway.

Britney Daniels, Maria V Hughes, Patti Ludwig-Beymer

    Journal of Emergency Nursing
    |January 14, 2026
    PubMed
    Summary

    This quality improvement project enhanced sickle cell pain management by promoting intranasal fentanyl. While not statistically significant, it reduced time to analgesia for pediatric patients experiencing vaso-occlusive crises.

    Keywords:
    Emergency departmentIntranasal fentaNYLPediatricsQuality improvementSickle cell diseaseVaso-occlusive pain

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    Area of Science:

    • Pain Management
    • Quality Improvement
    • Pediatric Hematology

    Background:

    • Sickle cell disease patients frequently experience acute pain crises requiring emergency department visits.
    • Current care often involves delays in analgesia and invasive procedures.
    • This project focused on improving timely pain management for sickle cell patients.

    Purpose of the Study:

    • To enhance the timely administration of pain medication for sickle cell disease patients.
    • To increase adherence to an established pain management pathway.
    • To promote the use of intranasal fentanyl as a first-line analgesic.

    Main Methods:

    • Implemented a quality improvement initiative with multiple interventions.
    • Introduced a standard operating procedure for safe intranasal fentanyl use.
    • Utilized electronic health record best practice advisories and educational materials.

    Main Results:

    • The time to pain medication administration decreased from a mean of 82.2 to 67.7 minutes.
    • The median time to pain medication administration decreased from 65 to 59 minutes.
    • While trends showed improvement, the change did not reach statistical significance (P = .2201).

    Conclusions:

    • Increased adherence to an intranasal fentanyl protocol reduced time to opioid administration for pediatric sickle cell patients.
    • Standardized pain management pathways improve efficiency and equity in care.
    • Findings support the benefits of established protocols for managing vaso-occlusive crises.