Intestinal Atresia in Finland: Maternal Risk Factors, Prevalence, Associated Anomalies and Survival
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View abstract on PubMed
Summary
This summary is machine-generated.Congenital intestinal atresia has low mortality despite frequent associated anomalies. Maternal insulin and propionic acid derivative use are linked to increased jejunoileal atresia risk.
Area Of Science
- Pediatric Surgery
- Medical Genetics
- Public Health
Background
- Congenital intestinal atresia (CIA) encompasses jejunoileal atresia (JIA) and colonic atresia (CA).
- Understanding prevalence, associated anomalies, and survival is crucial for clinical management.
- Identifying maternal risk factors can inform preventative strategies.
Purpose Of The Study
- To determine the prevalence and associated anomalies of CIA in Finland.
- To assess survival rates for JIA and CA.
- To investigate maternal risk factors for JIA.
Main Methods
- Retrospective analysis of CIA cases (1987-2019) from the Finnish Register of Congenital Malformations.
- Inclusion of clinical data from national health registers.
- Case-control study for maternal risk factors in JIA (2004-2017), comparing 101 cases with 5 matched controls each.
Main Results
- 175 JIA and 48 CA cases identified; approximately 50% were isolated anomalies.
- Common associated defects included gastrointestinal (26% JIA, 35% CA), cardiac (13% JIA), and urinary tract (19% CA).
- Survival rates were 88% for JIA and 94% for CA; only two deaths were directly attributed to intestinal atresia. Maternal insulin use (aOR 8.4) and propionic acid derivatives (aOR 4.6) increased JIA risk.
Conclusions
- Intestinal atresia has a low mortality rate, even with frequent co-occurring anomalies.
- Maternal use of insulin and propionic acid derivatives may be significant risk factors for developing jejunoileal atresia.
- Further research into these maternal exposures is warranted.
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