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Updated: Jan 17, 2026
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
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Early Transition Metal-Based Antitumor Complexes
Xinyi Li1, Xuanqi Fu2, Xiaojie Pu1
1School of Pharmacy, Changzhou University, Changzhou, P. R. China.
Chemistry, an Asian Journal
|January 14, 2026
Summary
Early transition metal complexes show promise as novel anticancer drugs. These compounds offer multiple therapeutic advantages, potentially leading to more effective precision tumor treatments.
Area of Science:
- Inorganic Chemistry
- Medicinal Chemistry
- Oncology
Background:
- Cancer remains a significant global health threat, driving the need for novel, low-toxicity anticancer therapies.
- Transition metal complexes offer unique advantages over traditional chemotherapy, including multi-site targeting to overcome drug resistance and tunable structures for enhanced efficacy.
Purpose of the Study:
- To review recent advancements in the anticancer effects of early transition metal complexes.
- To highlight the therapeutic potential of these complexes in precision oncology.
Main Methods:
- Literature review of studies on early transition metal complexes (Ti, V, Cr, Mn, Mo, Tc, Re) with anticancer activity.
- Analysis of their mechanisms of action, therapeutic capabilities, and potential for integrated diagnosis and treatment.
Main Results:
- Early transition metal complexes exhibit diverse anticancer mechanisms and therapeutic potential.
- These complexes demonstrate advantages such as reduced drug resistance and capabilities for photodynamic/photothermal therapy.
Conclusions:
- Early transition metal complexes represent a promising new class of anticancer agents.
- Further research and technological development may establish these metal-based drugs as key components in precision medicine for cancer treatment.
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