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Related Concept Videos

Properties of Transition Metals02:58

Properties of Transition Metals

29.6K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.6K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.2K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.2K
Colors and Magnetism03:02

Colors and Magnetism

14.0K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.0K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

24.0K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.0K
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

798
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
798
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

1.3K
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
1.3K

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Early Transition Metal-Based Antitumor Complexes.

Xinyi Li1, Xuanqi Fu2, Xiaojie Pu1

  • 1School of Pharmacy, Changzhou University, Changzhou, P. R. China.

Chemistry, an Asian Journal
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

Early transition metal complexes show promise as novel anticancer drugs. These compounds offer multiple therapeutic advantages, potentially leading to more effective precision tumor treatments.

Keywords:
cancer therapeuticsearly transition metaltransition metal complex

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Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Oncology

Background:

  • Cancer remains a significant global health threat, driving the need for novel, low-toxicity anticancer therapies.
  • Transition metal complexes offer unique advantages over traditional chemotherapy, including multi-site targeting to overcome drug resistance and tunable structures for enhanced efficacy.

Purpose of the Study:

  • To review recent advancements in the anticancer effects of early transition metal complexes.
  • To highlight the therapeutic potential of these complexes in precision oncology.

Main Methods:

  • Literature review of studies on early transition metal complexes (Ti, V, Cr, Mn, Mo, Tc, Re) with anticancer activity.
  • Analysis of their mechanisms of action, therapeutic capabilities, and potential for integrated diagnosis and treatment.

Main Results:

  • Early transition metal complexes exhibit diverse anticancer mechanisms and therapeutic potential.
  • These complexes demonstrate advantages such as reduced drug resistance and capabilities for photodynamic/photothermal therapy.

Conclusions:

  • Early transition metal complexes represent a promising new class of anticancer agents.
  • Further research and technological development may establish these metal-based drugs as key components in precision medicine for cancer treatment.