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Updated: Jan 17, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Autonomous robotic intraocular surgery for targeted retinal injections.

Gui-Bin Bian¹, Yawen Deng², Zhen Li¹

¹State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Science Robotics

|January 14, 2026

Summary

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Multimodal information-fused embodied intelligence toward autonomous robotic microsurgery.

Innovation (Cambridge (Mass.))·2026

An autonomous robotic system for intraocular surgery (ARISE) was developed, improving surgical precision and safety. This innovation enhances consistency and reduces errors in delicate eye surgeries.

Area of Science:

Ophthalmology
Robotics
Medical Technology

Background:

Intraocular surgery faces challenges in environmental perception and instrument depth estimation.
Autonomous surgery offers enhanced consistency, improved patient safety, and reduced training times.
Current limitations hinder widespread adoption in remote or extreme environments.

Purpose of the Study:

To develop an autonomous robotic system for intraocular surgery (ARISE).
To achieve targeted retinal injections with enhanced precision and safety.
To demonstrate the clinical feasibility of autonomous microsurgical robots.

Main Methods:

Developed the ARISE system with multiview spatial fusion for accurate imaging and positioning.
Implemented criterion-weighted multisensor data fusion to mitigate detection inconsistencies.

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Published on: March 7, 2025

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Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research

Published on: November 2, 2018

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Published on: March 7, 2025

Validated the system through subretinal and vascular injections in phantoms and animal models.

Main Results:

Achieved 100% success rates for subretinal, CRV, and BRV injections in ex vivo and in vivo models.
Reduced positioning errors by 79.87% compared to manual surgery and 54.61% compared to teleoperated robotic surgery.
Demonstrated enhanced injection precision, safety, and consistency in autonomous intraocular procedures.

Conclusions:

The ARISE system shows significant potential for autonomous intraocular microsurgery.
Autonomous robotic surgery can overcome current limitations in precision and consistency.
This technology promises to improve patient outcomes and expand surgical accessibility.