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Morphometric Analyses of Retinal Sections
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Structure-Function Correlation Using a Targeted Image-Guided Microperimetry Approach for Retinal Atrophic Diseases: A

Rubbia Afridi1, M Sohail Halim1, Mohamed Ahmed1

  • 1Byers Eye Institute, Stanford University Medicine, Palo Alto, CA, USA.

Translational Vision Science & Technology
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

This study shows targeted, image-guided microperimetry (IGMP) is a feasible method for assessing retinal atrophic diseases. This approach enhances structure-function correlation and optimizes microperimetry integration for clinical trials.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Retinal atrophic diseases like geographic atrophy (GA) and Stargardt disease (SD) require accurate functional assessment.
  • Current methods for assessing retinal function can be time-consuming and may not precisely map to structural lesions.

Purpose of the Study:

  • To evaluate the feasibility of a novel targeted, image-guided microperimetry (IGMP) workflow.
  • To integrate optical coherence tomography (OCT) and fundus autofluorescence (FAF) for precise lesion mapping and functional assessment in patients with retinal atrophic diseases.

Main Methods:

  • Twenty-two eyes (17 with early GA, 5 with SD) were analyzed.
  • Disease transition zones identified via OCT and FAF were mapped onto en face infrared images.
  • Microperimetry (MP) data was exported to custom MATLAB applications for IGMP pattern creation, followed by scans using MAIA and Nidek-MP3/S microperimeters.

Main Results:

  • Targeted IGMP proved quicker for assessing both SD and GA lesions compared to the standard 10-2 grid.
  • SD cases exhibited longer procedure/examination times and lower retinal sensitivity than GA lesions.
  • The IGMP approach demonstrated 100% feasibility and 100% algorithm compatibility across both tested MP devices (MAIA and Nidek-MP3/S).

Conclusions:

  • The study successfully established the feasibility of an IGMP workflow for targeted functional assessments in retinal degenerative diseases.
  • This approach shows promise for enhancing structure-function correlation and improving the efficiency of MP integration in clinical trials.
  • Further validation in larger patient cohorts is recommended to confirm broader clinical applicability.