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Klotho protein and insulin resistance
Yaqin Cai1, Bin Liu2, Dandan Song1
1Department of Clinical Laboratory and Department of Anesthesiology, Zhuhai 5th People's Hospital, Zhuhai, Guangdong 519055, China.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 14, 2026
Summary
Klotho protein levels are reduced in type 2 diabetes and linked to insulin resistance. Lower Klotho may predict diabetes risk and indicate Klotho
Area of Science:
- Endocrinology and Metabolism
- Gerontology and Aging Research
- Nephrology
Background:
- Klotho is an anti-aging protein with significant cardiorenal benefits.
- Klotho deficiency is linked to age-related diseases and renal impairment.
- Reduced serum Klotho is observed in type 2 diabetes (T2DM) and correlates with disease duration.
Purpose of the Study:
- To review the relationship between Klotho and insulin resistance (IR) in the context of T2DM.
- To explore Klotho's potential role in the pathogenesis of T2DM and IR.
Main Methods:
- Comprehensive literature review using PubMed.
- Keywords: "Klotho", "Type 2 diabetes", "Insulin resistance".
Main Results:
- Klotho expression is closely correlated with insulin secretion, signaling pathways, and insulin sensitivity.
- Serum Klotho levels are significantly decreased in T2DM patients.
Conclusions:
- Klotho may be involved in the pathological mechanisms of T2DM.
- Klotho may serve as a potential predictive marker for IR and T2DM risk.
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