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Related Experiment Video

Updated: Jan 17, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

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Published on: January 4, 2018

Klotho protein and insulin resistance.

Yaqin Cai¹, Bin Liu², Dandan Song¹

¹Department of Clinical Laboratory and Department of Anesthesiology, Zhuhai 5th People's Hospital, Zhuhai, Guangdong 519055, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|January 14, 2026

Summary

Klotho protein levels are reduced in type 2 diabetes and linked to insulin resistance. Lower Klotho may predict diabetes risk and indicate Klotho

Keywords:

HOMA-IR Insulin resistance Klotho TyG index Type 2 diabetes

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Last Updated: Jan 17, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

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Published on: January 4, 2018

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Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

Area of Science:

Endocrinology and Metabolism
Gerontology and Aging Research
Nephrology

Background:

Klotho is an anti-aging protein with significant cardiorenal benefits.
Klotho deficiency is linked to age-related diseases and renal impairment.
Reduced serum Klotho is observed in type 2 diabetes (T2DM) and correlates with disease duration.

Purpose of the Study:

To review the relationship between Klotho and insulin resistance (IR) in the context of T2DM.
To explore Klotho's potential role in the pathogenesis of T2DM and IR.

Main Methods:

Comprehensive literature review using PubMed.
Keywords: "Klotho", "Type 2 diabetes", "Insulin resistance".

Main Results:

Klotho expression is closely correlated with insulin secretion, signaling pathways, and insulin sensitivity.
Serum Klotho levels are significantly decreased in T2DM patients.

Conclusions:

Klotho may be involved in the pathological mechanisms of T2DM.
Klotho may serve as a potential predictive marker for IR and T2DM risk.