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Fungal-derived supplements in integrative oncology.

Caroline Mohammed¹, Ashley E Aaroe², Greg Buchold²

¹Department of Neurology, University of North Carolina at Chapel Hill, NC, USA.

The American Journal of Medicine

|January 14, 2026

Summary

Fungal supplements show promise for cancer patients, offering immunomodulatory, neuroprotective, and antioxidant benefits. Further research is needed to integrate these natural therapies into conventional cancer care for improved patient well-being.

Keywords:

Antioxidant Fungal supplements Fungi Immunomodulation Integrative medicine Mushrooms Neuroprotection

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Area of Science:

Integrative Oncology
Pharmacology
Mycology

Background:

Growing interest in fungal-derived supplements for cancer patient support.
Preclinical and clinical studies suggest immunomodulatory, neuroprotective, and antioxidant effects of fungi.
Limited integration of these natural approaches in current cancer care practices.

Purpose of the Study:

To highlight the potential benefits of fungal supplements in cancer patient care.
To encourage greater investigation into the use of fungi as complementary therapies.
To promote the integration of fungal-derived supplements within an integrative medicine framework.

Main Methods:

Review of preclinical animal studies on fungal activities.
Analysis of human clinical studies supporting fungal benefits.
Compilation of examples demonstrating positive patient well-being impacts.

Main Results:

Fungal supplements exhibit significant immunomodulatory, neuroprotective, and antioxidant properties.
Evidence from both animal and human studies supports these therapeutic potentials.
Documented cases show positive contributions to patients' overall well-being.

Conclusions:

Fungal-derived supplements offer a promising avenue for enhancing cancer patient care.
There is a need for increased healthcare professional utilization and investigation of these natural products.
Integrating fungal supplements into cancer treatment plans can support patient well-being.