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Reflection of the Impact of COVID-19 Infection on Vascular Surgery Outcomes: A Multicenter Analysis of Peripheral

Sabrina Straus1, Nadin Elsayed2, William P Robinson2

  • 1Division of Vascular and Endovascular Surgery, Department of Surgery, UC San Diego (UCSD), San Diego, CA.

Annals of Vascular Surgery
|January 14, 2026
PubMed

Insights

COVID-19 significantly increases risks for vascular surgery patients, especially those undergoing peripheral vascular interventions (PVI). Outcomes include higher mortality, limb loss, and complications, necessitating careful patient management.

Area of Science:

  • Vascular Surgery
  • Infectious Disease Epidemiology
  • Patient Outcomes Research

Background:

  • The impact of COVID-19 on vascular surgery patients is not fully understood.
  • Patients with pre-existing vascular disease may face heightened risks.
  • This study investigates outcomes in COVID-19 patients undergoing vascular procedures.

Purpose of the Study:

  • To describe postoperative outcomes in COVID-19 patients undergoing vascular procedures.
  • To assess one-year survival rates in this patient cohort.
  • To utilize a multicenter, real-world dataset for comprehensive analysis.

Main Methods:

  • Retrospective review of patients undergoing peripheral vascular interventions (PVI) and infrainguinal bypass.
  • Data sourced from the Vascular Quality Initiative (2020-2022).
  • Statistical analyses included multivariable logistic regression and survival analyses (Kaplan-Meier, Cox regression).

Main Results:

  • COVID-19 patients undergoing PVI experienced higher in-hospital mortality (10.9% vs 1.8%), amputation (17.7% vs 10.6%), renal (4.1% vs 1.8%), and pulmonary complications (6.8% vs 1.2%).
  • COVID-19 patients undergoing infrainguinal bypass had increased risk of ipsilateral amputation (OR: 1.6).
  • One-year mortality was significantly higher for COVID-19 PVI patients (HR: 2.1).

Conclusions:

  • COVID-19 patients undergoing PVI face substantially elevated risks of complications, limb loss, and mortality.
  • Infrainguinal bypass patients with COVID-19 also showed an increased risk of limb loss.
  • Recommendations include optimizing medical care, close monitoring, and considering deferral of elective vascular procedures.
Abstract

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