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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Changes in Cardiac Function in Patients Receiving Radiation Therapy for Lung Cancer.

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  • 1Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
|January 14, 2026
PubMed
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Radiation therapy for non-small cell lung cancer (NSCLC) can cause temporary cardiac dysfunction, particularly affecting left ventricular ejection fraction (LVEF). Whole heart V30 is a key dose metric linked to these declines, highlighting its importance in radiation planning.

Keywords:
Cardiac dosimetryCardiac functionCardiac toxicityNSCLCRadiation therapy

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Area of Science:

  • Cardiology
  • Oncology
  • Radiology

Background:

  • Cardiovascular toxicity from radiation therapy (RT) in non-small cell lung cancer (NSCLC) patients is not fully understood.
  • Echocardiographic changes and their correlation with cardiac dose-volume metrics require further investigation.

Purpose of the Study:

  • To assess changes in echocardiographic parameters of cardiac structure and function following RT in NSCLC patients.
  • To identify associations between these echocardiographic changes and cardiac dose-volume metrics.

Main Methods:

  • A multi-center, prospective cohort study involving NSCLC patients undergoing thoracic RT.
  • Echocardiograms were collected at baseline, end of RT, and at 6 and 12 months post-RT.
  • Repeated-measures multivariable linear regression analyzed changes in echocardiographic measures and dose-volume associations.

Main Results:

  • Modest, largely reversible declines in left ventricular ejection fraction (LVEF), global longitudinal strain, and circumferential strain were observed post-RT.
  • Cardiac dysfunction (LVEF decline ≥10% to <50%) occurred in 7.2% of participants.
  • Mean heart dose (MHD) and whole heart V30 were associated with LVEF declines, with whole heart V30 remaining significant after adjustment.

Conclusions:

  • RT in NSCLC patients leads to modest, temporary cardiac function changes, with a subset experiencing significant dysfunction.
  • Whole heart V30 is a relevant metric for RT planning due to its association with LVEF decline.
  • Further research into novel dose-volume measures is warranted.