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Prostate Diffusion-weighted Imaging: Selecting the Optimal Repetition Time Using Synthetic Imaging Techniques.

Atsushi Higaki1, Tsutomu Tamada1, Mitsuru Takeuchi2

  • 1Department of Radiology, Kawasaki Medical School, Kurashiki Okayama, Japan.

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|January 14, 2026
PubMed
Summary
This summary is machine-generated.

Optimizing prostate diffusion-weighted imaging (DWI) requires adjusting the repetition time (TR). Shorter TRs (1000-1500 ms) enhance lesion conspicuity and background suppression for better prostate cancer detection.

Keywords:
diffusion-weighted imagingprostate cancerrepetition time

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Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Prostate diffusion-weighted imaging (DWI) plays a crucial role in detecting and characterizing prostate cancer.
  • The optimal repetition time (TR) for prostate DWI is not well-established, impacting image quality and diagnostic accuracy.

Purpose of the Study:

  • To evaluate the effect of different TR values on prostate DWI parameters.
  • To determine the optimal TR for balancing contrast, signal-to-noise ratio (SNR), and lesion conspicuity in prostate cancer detection.

Main Methods:

  • Synthetic DWI datasets (b=2000 s/mm²) were acquired from 33 patients with 56 clinically significant prostate cancers.
  • Images were compared across TR values of 500, 1000, 1500, and 2000 ms against a conventional TR of 6000 ms.
  • Image quality was assessed using contrast ratio, apparent SNR, lesion conspicuity, PI-RADS v2.1 DWI scores, and background suppression.

Main Results:

  • TR6000 ms showed lower contrast ratio but higher apparent SNR than shorter TRs.
  • TR 1000-2000 ms improved lesion conspicuity compared to TR 500 ms.
  • TR 1500-6000 ms yielded higher DWI scores than TR 500 ms.
  • TR 500-1500 ms provided superior background suppression compared to TR 2000/6000 ms.

Conclusions:

  • TR 1000 ms or TR 1500 ms are recommended for prostate DWI to achieve an optimal balance between contrast and noise.
  • These TR values may enhance the detection of prostate cancer in clinical practice.