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Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization
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How to Treat Carbapenem-Resistant Acinetobacter baumannii Infections: Current Knowledge and Personal Viewpoints
Antonio Cascio1, Luca Pipitò1, David L Paterson2
1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro", University of Palermo, 90133 Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the Fight Against AIDS, AOU Policlinico "P. Giaccone", 90133 Palermo, Italy.
Abstract:
Acinetobacter baumannii, particularly carbapenem-resistant strains (CRAB), represents a critical global health threat due to its multidrug resistance and association with severe healthcare-associated infections. Treatment options remain limited, with high mortality rates observed in ventilator-associated pneumonia (VAP), bloodstream infections (BSI), and central nervous system (CNS) infections. Colistin-based regimens, despite toxicity and pharmacokinetic limitations, have long been standard therapy. Recent therapeutic advances include cefiderocol and sulbactam/durlobactam, which show potential activity, especially when used in combination regimens.
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