Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Ribosome Profiling

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...

Bone Structure

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Animal models for critical-sized long-bone defects and long-bone non-union: a scoping review.

Journal of orthopaedic surgery and research·2026

Same author

Transient Early Mechanical Loading Induces Hypertrophic Chondrocyte Differentiation of Human Mesenchymal Stromal Cells.

Cells·2025

Same author

Influence of Age on Fracture Healing in Young and Middle-Aged Mice in a Proximal Femur Fracture Model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2025

Same author

In Vitro Induction of Hypertrophic Chondrocyte Differentiation of Naïve MSCs by Strain.

Cells·2025

Same author

Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics.

Science advances·2025

Same author

Prognostic and therapeutic potential of microRNAs for fracture healing processes and non-union fractures: A systematic review.

Clinical and translational medicine·2023

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

Advances in Spatial Transcriptomics in Bone.

Nico Valerio Giger^1,2, Esther Wehrle³

¹AO Research Institute Davos, Clavadelerstrasse 8, 7270, Davos Platz, Switzerland.

Current Osteoporosis Reports

|January 14, 2026

Summary

This summary is machine-generated.

Spatial transcriptomics reveals bone

Keywords:

Bone Bone development Fracture healing Multi-omics Sample preparation Spatial transcriptomics

More Related Videos

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Related Experiment Videos

Last Updated: Jan 16, 2026

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Area of Science:

Bone biology and skeletal research.
Molecular and cellular biology.
Biotechnology and bioengineering.

Background:

Spatial transcriptomics allows detailed analysis of gene expression within the bone microenvironment.
Understanding the spatial distribution of cells and molecules is crucial for bone health and disease.

Purpose of the Study:

To review recent applications of spatial transcriptomics in bone research.
To highlight the potential of spatial transcriptomics for skeletal development, bone disorders, and fracture healing.
To discuss its role in advancing basic and translational research.

Main Methods:

Review of current literature on spatial transcriptomics techniques applied to bone tissue.
Analysis of recent advancements in sample preparation and data analysis for bone spatial transcriptomics.
Discussion of integration with multi-omics and multi-modal imaging.

Main Results:

Spatial transcriptomics is now applicable to bone due to improved sample preparation.
Standardized analysis pipelines and larger sample sizes are needed for bone spatial transcriptomics.
This technology is key to understanding bone's molecular and spatial complexity.

Conclusions:

Spatial transcriptomics is a foundational technology for bone research.
Integration with other 'omics' and imaging approaches will enhance translational research in orthopaedics and musculoskeletal fields.
Further development is needed to overcome current limitations in data analysis and sample size.