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Updated: Jan 16, 2026

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
CD8+ T cell aging, senescence, and related disease
Zhe He1, Fei Guo1, Qifan Zhao1
1Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
None:
CD8+ T cells are the primary killer cells that fight infections and malignantly transformed cells in vivo. In response to various stimuli, activated CD8+ T cells differentiate into effector and memory CD8+ T cells, which eliminate target cells and provide long-term protective immunity, respectively. Aberrant CD8+ T cell function induced by aging can lead to immune-related disorders. Both endogenous and exogenous stress affect the aging process of CD8+ T cells. CD8+ T cell aging results in cell senescence, characterized by disrupted cell proliferation, and impairs many other CD8+ T cell-related immune responses. It is now well-established that the aging of immune cells, including CD8+ T cells, exacerbates the body's inflammation and promotes cell senescence in distant tissues, thereby accelerating the onset and progression of age-related diseases. Therefore, clarifying the genetic characteristics, molecular mechanisms, and specific markers of aged CD8+ T cells is crucial for delivering precise and effective therapeutic interventions for age-related diseases, particularly those induced by CD8+ T cell aging.
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