Related Experiment Video
Updated: Jan 17, 2026
04:43
Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
Published on: May 23, 2025
743
Interventions to Prevent Postinflammatory Hyperpigmentation After Laser and Energy-Based Device Treatments: A
Supisara Wongdama1, Sasitorn Yenyuwadee1, Jayne Bernadeth Li1
1Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Lasers in Surgery and Medicine
|January 14, 2026
Summary
Intradermal tranexamic acid (TXA) and topical corticosteroids are most effective for preventing postinflammatory hyperpigmentation (PIH) after laser treatments. These interventions offer better protection than sunscreen alone, guiding clinical practice for optimal patient outcomes.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Evidence-Based Medicine
Background:
- Postinflammatory hyperpigmentation (PIH) is a frequent complication of laser therapy.
- Current prophylactic strategies for laser-induced PIH lack definitive comparative efficacy data.
Conclusions:
- Topical corticosteroids and intradermal TXA represent superior prophylactic options against laser-induced PIH compared to sunscreen.
- Integrating evidence-based preventive strategies is crucial for laser treatment planning, especially for high-risk individuals.
- An individualized approach to PIH prevention is recommended, acknowledging the limitations of current trial data.
