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[Exercise-induced asthma and placebos].

S Schwank, K Kyd, M Scherrer

    Schweizerische Medizinische Wochenschrift
    |February 18, 1978
    PubMed
    Summary
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    Placebo significantly protected patients with exercise-induced asthma (EIA), demonstrating a greater effect than anticipated. This highlights the powerful role of patient trust in managing EIA symptoms.

    Area of Science:

    • Pulmonology
    • Clinical Pharmacology
    • Psychosomatic Medicine

    Background:

    • Exercise-induced asthma (EIA) is characterized by a significant decrease in FEV1 post-exercise.
    • The psychological impact of placebos in managing respiratory conditions requires further investigation.

    Purpose of the Study:

    • To evaluate the effectiveness of placebo in patients with EIA.
    • To differentiate the psychological effects of placebo from environmental factors in a clinical setting.
    • To compare placebo efficacy against a known asthma medication, Cromolyn.

    Main Methods:

    • 15 patients with EIA underwent treadmill tests.
    • A subset of 7 patients repeated tests to control for environmental and procedural influences.
    • 14 patients received either placebo or Cromolyn before exercise, with FEV1 measurements taken post-exercise.

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    Main Results:

    • Placebo demonstrated statistically significant protection against EIA (p < 0.025).
    • Cromolyn provided superior protection compared to placebo (p < 0.005).
    • Placebo's protective effect in EIA was notably greater than previously observed in other asthma types.

    Conclusions:

    • Placebo exerts a significant protective effect in exercise-induced asthma, exceeding prior expectations.
    • The high efficacy of placebo in EIA, when environmental influences are controlled, is attributed to patient trust.
    • While effective, placebo's protective benefit is surpassed by that of Cromolyn.