Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improvement of thermostability and catalytic efficiency of glucoamylase from Talaromyces leycettanus JCM12802 via site-directed mutagenesis to enhance industrial saccharification applications.

Biotechnology for biofuels·2021
Same author

Heterologous expression and characterization of thermostable chitinase and β-N-acetylhexosaminidase from Caldicellulosiruptor acetigenus and their synergistic action on the bioconversion of chitin into N-acetyl-d-glucosamine.

International journal of biological macromolecules·2021
Same author

Factors shaping soil organic carbon stocks in grass covered orchards across China: A meta-analysis.

The Science of the total environment·2021
Same author

Quantitative insights on de/repolymerization and deoxygenation of lignin in subcritical water.

Bioresource technology·2021
Same author

Efficient Degradation of Zearalenone by Dye-Decolorizing Peroxidase from <i>Streptomyces thermocarboxydus</i> Combining Catalytic Properties of Manganese Peroxidase and Laccase.

Toxins·2021
Same author

Identifying Needs and Barriers to Diabetes Dietary Education in Chinese People with Type 2 Diabetes and Their Family Members in Guangzhou: A Qualitative Study.

Diabetes, metabolic syndrome and obesity : targets and therapy·2021

Related Experiment Video

Updated: May 10, 2026

Magnetic Adjustment of Afterload in Engineered Heart Tissues
09:40

Magnetic Adjustment of Afterload in Engineered Heart Tissues

Published on: May 5, 2020

6.2K

Sympathetic-like-integrated engineered heart tissue models AGEs-induced adverse remodeling.

Yu-Hong Wang1,2, Xi-Ming Zhu1, Xiang Long2,3

  • 1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China.

Cardiovascular Diabetology
|January 15, 2026
PubMed
Summary

A new Sympathetic-like-Integrated Engineered Heart Tissue (SIEHT) model better mimics neuro-cardiac interactions and disease. This advanced engineered heart tissue (EHT) tool aids in understanding cardiovascular metabolic diseases (CMDs).

Keywords:
AGEsCardiometabolic diseasesEngineered heart tissueInnervationiPSC-CM

More Related Videos

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.5K
Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

3.0K

Related Experiment Videos

Last Updated: May 10, 2026

Magnetic Adjustment of Afterload in Engineered Heart Tissues
09:40

Magnetic Adjustment of Afterload in Engineered Heart Tissues

Published on: May 5, 2020

6.2K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

5.5K
Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
12:28

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

3.0K

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Neuroscience

Background:

  • Cardiovascular metabolic diseases (CMDs) are a leading cause of death, but their mechanisms are poorly understood.
  • Current in vitro models, like engineered heart tissues (EHTs), lack neural components and cannot fully replicate complex neuro-cardiac interactions crucial for CMDs.

Purpose of the Study:

  • To develop a novel neuron-like-Integrated Engineered Heart Tissue (SIEHT) for studying neuro-cardiac interactions.
  • To provide an advanced tool for investigating physiological and pathological conditions in CMD research.

Main Methods:

  • Constructed Sympathetic-like-Integrated Engineered Heart Tissue (SIEHT) by integrating sympathetic-like neurons into EHT.
  • Compared SIEHT and conventional EHT structural/functional properties using morphological, molecular, and contractility analyses.
  • Assessed AGEs-induced pathological remodeling in SIEHT via cell viability, oxidative stress, contractility, and transcriptomics.

Main Results:

  • SIEHT showed enhanced structural and functional maturation compared to EHT, with better cardiomyocyte alignment and contractility.
  • Pathological conditions (AGEs) induced more severe dysfunction, neural injury, and abnormal beating in SIEHT.
  • Transcriptomic analysis revealed enriched AGE-RAGE signaling pathways relevant to diabetic complications.

Conclusions:

  • Successfully developed a novel SIEHT model that replicates physiological neuro-cardiac interactions.
  • The SIEHT model effectively recapitulates adverse remodeling in response to AGEs, offering insights into CMD pathophysiology.
  • This innovative model serves as a powerful tool for understanding neuro-cardiac dysregulation in cardiovascular metabolic diseases.