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Beyond the Forest Plot: Redefining Model-Based Meta-Analysis as a Quantitative Engine for Model-Informed Drug

Bhavatharini Sukumaran1, Rinu Mary Xavier1, Aswathy Vs2

  • 1Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India.

Drug Development Research
|January 15, 2026
PubMed
Summary

Model-Based Meta-analysis (MBMA) enhances drug development by integrating pharmacometric modeling with traditional meta-analysis. This advanced method provides predictive insights for dose selection and treatment effects, overcoming limitations of standard evidence synthesis.

Keywords:
Bayesian hierarchical modelsModel‐Based Meta‐Analysis (MBMA)Model‐Informed Drug Development (MIDD)dose‐response modelingpharmacometrics

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