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Related Experiment Video

Updated: Jan 16, 2026

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Non-Infectious Fever Associated with Massive Upper Gastrointestinal Bleeding.

Aoi Kaneko1, Taku Harada1,2

  • 1Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan.

European Journal of Case Reports in Internal Medicine
|January 15, 2026
PubMed
Summary

Fever associated with gastrointestinal bleeding may be absorption fever, a non-infectious condition. Recognizing this prevents unnecessary antibiotics and supports antimicrobial stewardship.

Keywords:
Gastrointestinal bleedingabsorption feverantibiotic stewardshipnon-infectious feverpeptic ulcer

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Clinical Diagnostics

Background:

  • Fever is often treated with antibiotics, but non-infectious causes are frequently overlooked.
  • Absorption fever is a rare, under-recognized cause of fever in patients with gastrointestinal bleeding.
  • Early identification of absorption fever is crucial to avoid unnecessary antibiotic exposure.

Purpose of the Study:

  • To highlight absorption fever as a non-infectious cause of fever in upper gastrointestinal bleeding.
  • To emphasize the importance of differentiating absorption fever from infectious causes.
  • To promote appropriate management and antimicrobial stewardship.

Main Methods:

  • Case presentation of a 61-year-old male with upper gastrointestinal bleeding and fever.
  • Clinical evaluation including laboratory tests, computed tomography, and upper endoscopy.
  • Exclusion of infectious sources and observation of spontaneous fever resolution.

Main Results:

  • The patient presented with symptoms of upper gastrointestinal bleeding and fever.
  • Diagnostic workup ruled out infectious or malignant etiologies.
  • Fever resolved spontaneously, consistent with absorption fever, without antibiotic intervention.

Conclusions:

  • Absorption fever is a transient, non-infectious fever linked to gastrointestinal bleeding.
  • Clinical vigilance is essential to distinguish absorption fever from infection in febrile patients with GI bleeding.
  • Recognizing absorption fever aids in preventing unnecessary antibiotic use and supports antimicrobial stewardship.