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Lincomycin HCl-loaded nanoparticles: development, optimization, and incorporation into a nanogel for wound healing
Aisha Sethi1, Rabia Zaheer1, Shazia Akram Ghumman2
1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad-38000 Pakistan ayeshasethi786@gcuf.edu.pk rabiazaheer2018@gmail.com asifmassud@gmail.com.
RSC Advances
|January 15, 2026
Summary
This study developed lincomycin HCl (LCH)-loaded chitosan nanoparticles (CSNPs) in a nanogel for enhanced wound healing. The LCH-CSNP nanogel demonstrated effective antimicrobial action and accelerated wound closure in vivo.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Wound healing requires effective antimicrobial delivery and sustained drug release.
- Chitosan nanoparticles (CSNPs) offer a promising platform for drug delivery due to their biocompatibility and biodegradability.
- Developing advanced topical formulations is crucial for improving wound treatment outcomes.
Purpose of the Study:
- To develop and evaluate lincomycin HCl (LCH)-loaded CSNPs within a nanogel system.
- To assess the physicochemical properties, drug release kinetics, and antibacterial efficacy of the formulation.
- To investigate the in vivo wound healing potential of the LCH-CSNP nanogel.
Main Methods:
- CSNPs loaded with LCH were prepared using ionic gelation with sodium tripolyphosphate (STPP).
- Formulations were characterized for particle size, polydispersity index (PDI), zeta potential, and drug entrapment efficiency.
- Spectroscopic (FTIR, DSC, XRD) and release studies were conducted, followed by in vitro antibacterial assays and in vivo wound healing studies in rats.
Main Results:
- Optimized LCH-CSNPs exhibited a particle size of 174.3 nm, PDI of 0.267, zeta potential of +29.4 mV, and 83.7% entrapment efficiency.
- FTIR, DSC, and XRD confirmed successful drug encapsulation and formulation stability.
- Sustained drug release (>75% in 24 hours) followed non-Fickian kinetics, with significant antibacterial activity against S. aureus and E. coli.
- In vivo studies showed near-complete wound closure within 14 days in the LCH-CSNP nanogel treated group.
Conclusions:
- The developed LCH-CSNP nanogel system facilitates controlled lincomycin HCl release.
- The formulation exhibits potent antimicrobial properties and significantly accelerates wound healing in an in vivo model.
- This LCH-CSNP nanogel holds considerable potential as an advanced topical therapeutic platform for wound management.
