An in vitro study on macrophage toxicity of allotrope silver nanoparticles

Recent studies have established EVQ-218 as a novel type of allotrope silver nanoparticle (AgNP). The patented laser-based method of manufacture imparts EVQ-218 with unique surface properties that enhance particle stability without capping agents and other stabilizing chemistry. In this study, EVQ-218 was screened against RAW 264.7 murine macrophages, MH-S murine alveolar macrophages, and THP-1 human monocyte cell lines. IC₅₀ values were obtained, and cellular uptake and phagocytosis assays were conducted. Results of this study indicate that the intracellular uptake of EVQ-218 did not make any apparent physiologically significant change in cell morphology and phagocytic activity of macrophages at nontoxic doses.