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Location, Dissection, and Analysis of the Murine Stellate Ganglion
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Targeting sympathetic glia for treating cardiovascular diseases.

Alison Xiaoqiao Xie1, Angelo I Chaia2, Ken D McCarthy1

  • 1Department of Pharmacology, UNC-Chapel Hill, Chapel Hill, NC, 27599-7365 USA.

Receptors & Clinical Investigation
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Summary

Satellite glial cells (SGCs) in sympathetic ganglia modulate cardiac function via Gq-GPCR signaling. Targeting these glial cells shows potential for treating cardiovascular diseases (CVDs).

Keywords:
AAVGq-DREADDcardiovascular diseasespharmacogeneticssatellite glial cellssympathetic ganglia

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Area of Science:

  • Neuroscience
  • Cardiovascular Biology
  • Glial Cell Biology

Background:

  • Gq G protein-coupled receptor (Gq-GPCR) signaling in glial fibrillary acidic protein-expressing (GFAP+) glia is crucial for central nervous system (CNS) neuron-glia interactions.
  • The role of Gq-GPCR signaling in peripheral GFAP+ glia, specifically satellite glial cells (SGCs) in sympathetic ganglia, is an emerging area of research.
  • SGCs are implicated in modulating sympathetic nerve activity (SNA) and its impact on physiological and pathological processes.

Purpose of the Study:

  • To investigate the role of Gq-GPCR signaling in satellite glial cells (SGCs) of sympathetic ganglia.
  • To explore the modulation of sympathetic-regulated cardiac functions by SGCs.
  • To present a novel experimental approach for manipulating SGC signaling in sympathetic ganglia.

Main Methods:

  • Utilized adeno-associated virus (AAV) vectors for targeted manipulation of satellite glial cell signaling.
  • Investigated the functional impact of Gq-GPCR activation in SGCs on cardiac function.
  • Assessed the modulation of sympathetic nerve activity (SNA) by SGCs.

Main Results:

  • Demonstrated that Gq-GPCR activation in SGCs positively modulates sympathetic-regulated cardiac functions.
  • Showcased successful targeted viral transduction in ganglionic SGCs using AAV.
  • Established the significance of SGCs in regulating sympathetic nerve activity (SNA).

Conclusions:

  • Satellite glial cells (SGCs) play a significant role in modulating cardiac function through Gq-GPCR signaling.
  • Targeting sympathetic glia, particularly SGCs, presents a promising therapeutic strategy for cardiovascular diseases (CVDs).
  • The developed AAV-mediated gene delivery system offers a powerful tool for future research into sympathetic ganglia function.