Related Experiment Video
Updated: Jan 16, 2026
Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
Published on: January 20, 2022
Impact of Measured and Predicted Patient-Prosthesis Mismatch on Quality of Life Following Transcatheter Aortic Valve
Karim Al-Azizi1, Mohamad Bader Abo Hajar2, Taylor Pickering2
1Department of Cardiology, Baylor Scott & White The Heart Hospital Plano, Plano, Texas, USA.
Background:
While patient-prosthesis mismatch (PPM) after transcatheter aortic valve implantation (TAVI) has not been associated with increased mortality, its impact on quality of life (QoL) remains unclear.
Methods:
We retrospectively analyzed 3013 patients undergoing TAVI (2012-2022) within a large health care system. Patients were stratified by effective orifice area indexed to body surface area (EOAi) into no (EOAi >0.85 cm2/m2), moderate (EOAi >0.65 cm2/m2 or ≤0.85 cm2/m2), or severe (EOAi ≤0.65 cm2/m2) PPM, with lower cutoffs for obese patients (body mass index ≥30 kg/m2).
Results:
The median age was 80.0 (73.0; 86.0) years, and 55.6% were female with a median Society of Thoracic Surgery risk score of 4.70% (2.66; 7.64). Overall, TAVI led to significant improvements in New York Heart Association and Kansas City Cardiomyopathy Questionnaire scores at 30 days and 1 year. Severe predicted and severe measured PPm was not associated with inferior QoL outcomes improvement (all p > 0.05).
Conclusion:
In this large cohort, TAVI yielded substantial and durable QoL gains, regardless of PPM severity or valve type. These findings suggest that moderate or severe PPM does not diminish functional recovery and should not be a primary determinant in valve selection or procedural strategy at 1 year.
