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Updated: Jan 17, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Copper-Catalyzed Regioselective Dehydrogenative Borylation: A Modular Platform Enabling C4-Borylated
Xiu-Lian Zhang1, Wei-Jie Wang1, Hua-Wei Luan1
1School of Environmental and Chemical Engineering, Jiangsu Ocean University, Lianyungang 222005, China.
None:
The [2,1]-borazaronaphthalene scaffold is a valuable BN-isostere of naphthalene with significant potential in medicinal and materials chemistry, yet its precise C4-functionalization remains challenging. Herein, we report a copper-catalyzed, regioselective dehydrogenative borylation that enables direct C4-H borylation of [2,1]-borazaronaphthalenes using B2pin2. This method features a broad substrate scope, providing efficient access to diverse 4-boryl derivatives. The synthetic utility is demonstrated through gram-scale synthesis and downstream transformations, including the construction of axially chiral scaffolds, offering a versatile platform for diversifying these BN-heterocycles.
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