Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Bone Structure01:55

Bone Structure

51.5K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ADVANCING THE EFFICACY OF DENGUE PREVENTION AND CONTROL IN NEPAL AND BANGLADESH: TRANSFORMING BOUNDARIES INTO BRIDGES-A WORKSHOP SUMMARY.

Journal of the American Mosquito Control Association·2026
Same author

Elimination of visceral leishmaniasis as a public health problem in Bangladesh: Lessons learned and questions remaining.

PLoS neglected tropical diseases·2026
Same author

Molecular xenosurveillance of <i>Aedes</i> mosquitoes reveals dengue virus serotype-2 during an outbreak in Dhaka, Bangladesh.

Microbiology spectrum·2025
Same author

The Lifecycle of Phlebotomus argentipes (Diptera: Psychodidae) Sand Fly in a Newly Developed Colony in Bangladesh.

The American journal of tropical medicine and hygiene·2025
Same author

Bamboo stumps that are artificially in use put pressure on dengue and chikungunya vector control in Dhaka city, Bangladesh.

Journal of vector borne diseases·2024
Same author

Perceived needs of disease vector control programs: A review and synthesis of (sub)national assessments from South Asia and the Middle East.

PLoS neglected tropical diseases·2024

Related Experiment Video

Updated: Jan 17, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.2K

A multiscale optimization framework for bone remodelling: integrating material and structural adaptations across

Avinandan Modak1, Arijit Sau1, Rajib Chowdhury1

  • 1Department of Civil Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.

Journal of the Royal Society, Interface
|January 15, 2026
PubMed
Summary

This study presents a new framework for optimizing bone structure and material properties across all hierarchical levels. It mimics natural bone adaptation, offering insights into bone quality and potential therapeutic strategies.

Keywords:
bone remodellingconcurrent designcontinuum micromechanicshomogenizationmultiscale topology optimization

More Related Videos

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

2.1K
Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
08:39

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

559

Related Experiment Videos

Last Updated: Jan 17, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.2K
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

2.1K
Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects
08:39

Longitudinal Micro-Computed Tomography Image Analysis for User-Defined Region of Interest in Critical-Sized Bone Defects

Published on: June 24, 2025

559

Area of Science:

  • Biomaterials Science
  • Computational Biology
  • Biomechanics

Background:

  • Bone exhibits hierarchical organization across multiple length scales.
  • Adaptive remodeling integrates functional properties in bone.
  • Conventional remodeling approaches have limitations in capturing multi-scale behavior.

Purpose of the Study:

  • To present a concurrent material-structure optimization framework for bone.
  • To identify optimal macroscale bone density and microstructural configurations.
  • To efficiently capture bone's hierarchical material behavior.

Main Methods:

  • Formulated a compliance minimization problem with coupled material and structure optimization.
  • Leveraged a continuum micromechanics-based homogenization approach.
  • Applied the framework to a human proximal femur under musculoskeletal loading.

Main Results:

  • The framework captures self-optimizing mechanisms consistent with physiological adaptation.
  • Demonstrated computationally tractable optimization independent of hierarchical scales.
  • Identified optimal macroscale bone density and microstructural configurations.

Conclusions:

  • The framework provides a physics-based rationale for estimating microstructural distributions.
  • Highlights deviations that may inform future bone quality assessments.
  • Offers a foundation for targeted therapeutics, personalized diagnostics, and regenerative medicine.