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Updated: Aug 2, 2026
Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
Published on: July 16, 2018
Surgical Management of a Glioma-Associated Oncogene 1-Altered Mesenchymal Neoplasm Surrounding the Calcaneus: A Case
Jacob D Kodra1, Andrew Kleven1, S Krisztian Kovacs2
1Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Case:
A 23-year-old male with no medical history presented with a painless, slowly enlarging heel mass present for 5 years. Physical examination revealed a firm lesion with mild varicosities. Magnetic resonance imaging demonstrated a 4.3 × 1.7 × 4.2-cm lobular mass with peripheral enhancement. Advanced molecular workup confirmed a glioma-associated oncogene 1 (GLI1)-altered mesenchymal neoplasm-a rare, emerging tumor with evolving classification and diagnostic challenges. The mass was widely excised with negative margins, followed by free-flap reconstruction.
Conclusion:
GLI1-altered neoplasms are rare, unpredictable tumors requiring meticulous resection and multidisciplinary surveillance. This novel presentation from the subcutaneous soft tissue surrounding the calcaneus supports adequate excision and surveillance involving patient-specific considerations.
