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Related Concept Videos

Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Updated: Jan 17, 2026

Murine Full-thickness Skin Transplantation
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Delayed Full-Thickness Skin Grafting After Skin Cancer Resection: A Systematic Review.

Kishan S Shah1, Karishma S Shah2, Ajay N Sharma3

  • 1Department of Plastic & Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
|January 15, 2026
PubMed
Summary
This summary is machine-generated.

Delayed full-thickness skin grafts (FTSGs) are effective for reconstructing skin cancer defects after Mohs surgery or wide excision. Optimal graft success is achieved with a 2-3 week delay, offering favorable outcomes.

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Area of Science:

  • Dermatology
  • Plastic Surgery
  • Oncology

Background:

  • Reconstruction after Mohs micrographic surgery (MMS) or wide local excision (WLE) for skin cancer requires careful planning.
  • The use of delayed full-thickness skin grafts (FTSGs) in this context is not fully established.

Purpose of the Study:

  • To define the indications, surgical technique, and effectiveness of delayed FTSGs for skin cancer reconstruction.
  • To analyze outcomes of delayed FTSGs following MMS or WLE.

Main Methods:

  • Systematic review of 24 studies involving 665 patients undergoing delayed FTSG after skin cancer removal.
  • Data extraction on patient/tumor characteristics, surgical details, graft technique, success rates, complications, and aesthetic/functional results.

Main Results:

  • The average delay to grafting was 16.5 days, with an 89.6% success rate at 13 months follow-up.
  • Grafts placed 2-3 weeks post-excision showed better success than those placed within 1 week.
  • Overall outcomes were favorable, with high patient satisfaction.

Conclusions:

  • Delayed FTSGs are a highly effective reconstructive option for skin cancer defects.
  • A delay of 2-3 weeks appears optimal for maximizing graft success.