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Updated: May 6, 2026

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
Published on: October 17, 2016
Simultaneous ranging and force sensing on a single-mode fiber for minimally invasive interventions
This study introduces a novel fiber probe combining optical coherence tomography (OCT) for distance measurement and fiber Bragg grating (FBG) for force sensing. This integrated system enables precise, real-time feedback for minimally invasive procedures.
Area of Science:
- Biomedical Engineering
- Optical Sensing
- Minimally Invasive Surgery
Background:
- Minimally invasive interventions require precise real-time feedback on distance and force.
- Existing probes often lack integrated sensing capabilities, limiting their application in delicate procedures.
- Miniaturization and intrinsic alignment are crucial for effective endoscopic tools.
Purpose of the Study:
- To develop a compact, coaxial fiber probe integrating optical coherence tomography (OCT) ranging and fiber Bragg grating (FBG) force sensing.
- To enable synchronized distance-force feedback for enhanced control during minimally invasive interventions.
- To demonstrate the probe's utility in endoscopic palpation and subretinal injection procedures.
Main Methods:
- A coaxial fiber probe design incorporating a single-mode fiber with a short no-core and graded-index fiber segment.
- Utilizing OCT for precise distance measurement and FBG for force sensing.
- Developing a weakly focused beam to extend the depth of focus while maintaining a miniature probe design.
Main Results:
- The probe successfully distinguished stiff inclusions from surrounding tissue during endoscopic palpation.
- Simultaneous detection of contact and puncture was achieved during a subretinal injection model, evidenced by changes in distance and force.
- The integrated system demonstrated synchronized distance-force feedback capabilities.
Conclusions:
- The developed coaxial fiber probe offers a scalable platform for integrated optical sensing.
- This technology has significant potential for robotic microsurgery and other precision manipulation tasks.
- The probe's miniature design and synchronized feedback enhance safety and efficacy in minimally invasive interventions.
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